Date: July 16, 2019

Mainly cloudy with 60 percent chance of showers. Risk of a thunderstorm this afternoon. Wind southwest 20 km/h gusting to 40. High 29. Humidex 37. UV index 7 or high.

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Japanese Encephalitis Vaccine (Ixiaro®)

This page was reviewed or revised on Thursday, July 21, 2016 4:02 PM

Environmental Health & Prevention Services


What is Japanese Encephalitis

Japanese encephalitis (JE) is a viral disease that can cause severe inflammation of the brain.

It is spread to humans by the bite of an infected mosquito. In cannot spread from person-to-person. Mosquitoes are usually more active from dusk to dawn.

Symptoms include sudden onset of headache, high fever, confusion, and possible convulsions, coma and loss of movement. It can also be fatal.

JE is a seasonal disease that usually occurs in the summer and fall in the temperate regions of China, Japan, and Korea.

Who should get the JE vaccine?

The risk of JE is very low for most travellers, but higher for people living or travelling for long periods in areas where the disease is common. The risk also varies according to season, destination, duration, and activities.

  • Travellers, 18 years of age and older, who are going to high risk areas.
  • Travellers who will spend more than 30 days in rural or urban areas of risk.
  • Individuals staying in urban areas but making short trips to rural areas of risk.
  • Travellers who spend less than 30 days in rural or urban areas of risk, but will spend large amounts of time outdoors (or indoors without mosquito protection), especially in the evening or night.
  • Those who work with JE, in the lab or in industry.

The Japanese Encephalitis Vaccine

  • The vaccine is given as a 2-dose series, with the doses spaced 28 days apart.
  • The last dose should be given at least 1 week before travel.

Booster dose:

  • For those who are at a constant risk of exposure to JE, a booster is recommended every year with 1 dose of Ixiaro®.
  • If it has been more than 2 years since an individual has been vaccinated with Ixiaro®, 2 doses of Ixiaro®, at least 28 days apart, is recommended.

Who should NOT get the vaccine?

  • Children under 18 years of age.
  • If you have a fever or serious infection the day of vaccination.
  • If you are allergic to any ingredient in the vaccine.

Warnings and precautions

  • Pregnant women should only be given the vaccine if the benefits outweigh the risk to mother and baby. Talk with your doctor.
  • It is not known if the vaccine is excreted in the mother's milk. The vaccine should only be given if the benefits outweigh the risk to mother and child.